Search results for "Crohn ' s disease"

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THE VITAMIN D RECEPTOR TAQ I POLYMORPHISM IS ASSOCIATED WITH REDUCED VDR AND INCREASED PDIA3 PROTEIN LEVELS IN HUMAN INTESTINAL FIBROBLASTS

2020

The synonymous single nucleotide polymorphism (SNP) rs731236, located in the vitamin D receptor (VDR) gene (Taq I) has been associated with both decreased levels of the protein in peripheral blood mononuclear cells and a fibrosis-related complication in Crohn´s disease (CD). Interactions between VDR and a protein-disulfide isomerase-associated 3 (PDIA3) in the regulation of extracellular matrix have been reported and we aim to analyze the relevance of the VDR genotypes and the effects of Vitamin D (VD) in the expression of VDR, PDIA3 and proliferation of intestinal fibroblasts. Human intestinal fibroblasts were isolated from the non-affected surgical resections of colorectal patients and cl…

AdultMale0301 basic medicinemusculoskeletal diseasesAdolescentGenotypeEndocrinology Diabetes and MetabolismClinical BiochemistryProtein Disulfide-IsomerasesPDIA3BiologyPDIA3Polymorphism Single NucleotideBiochemistryPeripheral blood mononuclear cellCalcitriol receptorFibroblast migrationExtracellular matrixYoung Adult03 medical and health sciences0302 clinical medicineEndocrinologyVitamin D and neurologypolycyclic compoundsHumansGene silencingVitamin DMolecular BiologyAllelesCells CulturedCell ProliferationVDRdigestive oral and skin physiologyCell BiologyTransfectionFibroblastsMolecular biologySingle nucleotide polymorphismIntestines030104 developmental biologyCrohn ' s disease030220 oncology & carcinogenesisReceptors CalcitriolMolecular MedicineFemalelipids (amino acids peptides and proteins)Crohn´s diseaseTaq IJournal of steroid biochemistry and molecular biology
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